tert-butyl N-(4-chlorosulfonylphenyl)carbamate

tert-butyl N-(4-chlorosulfonylphenyl)carbamate - Names and Identifiers

Name	tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate
Synonyms	4-(BOC-AMINO)-BENZENESULFONYL CHLORIDE tert-butyl4-(chlorosulfonyl)phenylcarbamate ert-butylN-(4-chlorosulfonylphenyl)carbamate tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate TERT-BUTYL [4-(CHLOROSULFONYL)PHENYL]CARBAMATE tert-butyl N-(4-chlorosulfonylphenyl)carbamate 2-Methyl-2-propanyl [4-(chlorosulfonyl)phenyl]carbamate [4-(Chlorosulfonyl)phenyl]carbamic acid tert-butyl ester N-(4-chlorosulfonylphenyl)carbamic acid tert-butyl ester N-[4-(chlorosulfonyl)phenyl]carbamic acid 1,1-dimethylethyl ester Carbamic acid, N-[4-(chlorosulfonyl)phenyl]-, 1,1-dimethylethyl ester
CAS	269747-25-3

tert-butyl N-(4-chlorosulfonylphenyl)carbamate - Physico-chemical Properties

Molecular Formula	C11H14ClNO4S
Molar Mass	291.75
Density	1.356
Boling Point	346.7±25.0 °C(Predicted)
pKa	12.49±0.70(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

tert-butyl N-(4-chlorosulfonylphenyl)carbamate - Introduction

tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate is an organic compound whose chemical structural formula is N-Boc-C6H4SO2Cl. The following is a description of the nature, use, formulation and safety information of tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate:

Nature:
-Appearance: Colorless to light yellow solid
-molecular formula: C12H15ClNO4S
-Molecular weight: 303.77g/mol
-Melting point: 78-82 ° C
-Boiling point: 392.7 ° C
-Solubility: Soluble in common organic solvents, such as dimethyl sulfoxide (DMSO), methyl carbamate (DMF) and dimethylformamide (DMF), slightly soluble in ethanol, almost insoluble in water.

Use:
tert-Butyl [4-(chorosulfonyl) phenyl]carbamate is often used as an important reagent in organic synthesis and has the following uses:
-As an amino protection reagent: tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate can react with amine to generate the corresponding N-Boc-amine compound representing thionyl chloride group, thereby protecting the amino group, prevent unwanted reactions with other reagents.
-As a peptide synthesis reagent: tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate can be used for the introduction and removal of N-Boc protecting groups in peptide synthesis.
-Reagents in other organic synthesis reactions: tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate is also used in some other organic synthesis reactions, such as alkylation reactions.

Method:
tert-Butyl [4-(chorosulfonyl) phenyl]carbamate can be synthesized by the following steps:
1. First, P-aminobenzenesulfonic acid and tert-butyl carbonate (di-tert-butyl carbonate) are reacted in the presence of a base to obtain tert-butyl p-aminobenzenesulfonyl (tert-Butyl [4-aminophenyl]carbamate).
2. React p-aminobenzenesulfonyl tert-butyl ester with chloro sulfonyl chloride to generate tert-Butyl [4-(chloro sulfonyl)phenyl]carbamate.

Safety Information:
- tert-Butyl [4-(chlorosulfonyl)phenyl]carbamate is irritating and corrosive and should be avoided in contact with skin, eyes and respiratory tract. Appropriate protective equipment such as lab gloves, goggles and protective masks must be worn.
-in the use of the process should pay attention to explosion-proof measures, avoid contact with oxidants and flammable materials.
-It should be operated in a well-ventilated area and ensure that there are evacuation and countermeasures in emergency conditions.
-should be stored away from fire and high temperature, stored in a dry, cool place.

Last Update：2024-04-10 22:29:15